Blar i NTNU Open på forfatter "Kandasamy, Richard Kumaran"

Viser treff 1-20 av 23

    • Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response 

      Bösl, Korbinian; Giambelluca, Miriam; Haug, Markus; Bugge, Marit; Espevik, Terje; Kandasamy, Richard Kumaran; Bergstrøm, Bjarte Aune (Journal article; Peer reviewed, 2018)
      Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They ...

    • Common nodes of virus–host interaction revealed through an integrated network analysis 

      Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)
      Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ...

    • Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation 

      Pinto, Sneha M.; Kim, Hera; Subbannayya, Yashwanth; Giambelluca, Miriam S.; Bösl, Korbinian; Ryan, Liv; Sharma, Animesh; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2021)
      Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage ...

    • Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant 

      Soorajkumar, Anjana; Alakraf, Ebrahim; Uddin, Mohammed; Du Plessis, Stefan S.; Alsheikh-Ali, Alawi; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      Short linear motifs (SLiMs) are short linear sequences that can mediate protein–protein interaction. Mimicking eukaryotic SLiMs to compete with extra- or intracellular binding partners, or to sequester host proteins is the ...

    • Computational tools for exploring peptide-membrane interactions in gram-positive bacteria 

      Kumar, Shreya; Balaya, Rex Devasahayam Arokia; Kanekar, Saptami; Raju, Rajesh; Prasad, Thottethodi Subrahmanya; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2023)
      The vital cellular functions in Gram-positive bacteria are controlled by signaling molecules known as quorum sensing peptides (QSPs), considered promising therapeutic interventions for bacterial infections. In the bacterial ...

    • Deciphering role of succinate in metabolic rewiring of innate immunity 

      Sabbir, Ahmed (Master thesis, 2021)
      Succinate is the anionic form of succinic acid, which is produced during adenosine triphosphate (ATP) synthesis via the tricarboxylic acid (TCA) cycle. In a biological system, succinate can be found in two forms. One is ...

    • Decoding the Metabolic Reprogramming Underlying Toll-like Receptor Signaling 

      Kim, Hera (Doctoral theses at NTNU;2021:297, Doctoral thesis, 2021)

    • Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment 

      Najm, Rania; Hachim, Mahmood Yaseen; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic ...

    • Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling 

      Subbannayya, Yashwanth; Pinto, Sneha M.; Bösl, Korbinian; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)
      Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members ...

    • Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M 

      Hansen, Marianne Dore; Johnsen, Ingvild Bjellmo; Stiberg, Kim Andre Ha; Sherstova, Tatyana; Wakita, Takaji; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Meurs, Eliane F.; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2017)
      Positive-stranded RNA viruses, such as hepatitis C virus (HCV), assemble their viral replication complexes by remodeling host intracellular membranes to a membranous web. The precise composition of these replication complexes ...

    • Impact of DNA double-strand break response factors on B and T lymphocyte development 

      Castañeda-Zegarra, Sergio Miguel (Doctoral theses at NTNU;2022:224, Doctoral thesis, 2022)
      Sammendrag på norsk Virkningen av DNA-dobbeltrådbrudd responsfaktorer på B- og T-lymfocytt utvikling De mest cytotoksiske DNA-skadene i en celle er forårsaket av brudd på dobbelttrådet DNA (DSB). NHEJ er en essensiell ...

    • The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans 

      Agarwal, Shiuli; Vierbuchen, Tim; Ghosh, Sreya; Chan, Jennie; Jiang, Zhaozhao; Kandasamy, Richard Kumaran; Ricci, Emiliano; Fitzgerald, Katherine A. (Peer reviewed; Journal article, 2020)
      Long non-coding RNAs are important regulators of biological processes including immune responses. The immunoregulatory functions of lncRNAs have been revealed primarily in murine models with limited understanding of lncRNAs ...

    • Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells 

      Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.; Bjørås, Magnar; Espevik, Terje; Kaynov, Denis; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      COVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced extensive evidence on host-pathogen interactions and potential therapeutic ...

    • N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients 

      Jalaleddine, Nour; Hachim, Mahmood; Al-Hroub, Hamza; Saheb Sharif-Askari, Narjes; Senok, Abiola; Elmoselhi, Adel; Mahboub, Bassam; Samuel Kurien, Nimmi Moni; Kandasamy, Richard Kumaran; Semreen, Mohammad H.; Halwani, Rabih; Soares, Nelson C.; Al Heialy, Saba (Peer reviewed; Journal article, 2022)
      Despite the growing number of the vaccinated population, COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health burden. Obesity, a metabolic syndrome affecting one-third ...

    • Novel insights on human-virus interactions through genome-wide approaches 

      Bösl, Korbinian (Doctoral theses at NTNU;2019:113, Doctoral thesis, 2019)
      Virus er en viktig årsak til sykdom og død blant mennesker over hele verden. Symptomer påvirusinfeksjoner spenner fra lett forkjølelse til livstruende sykdomstilstand. Virale patogener som Human Immunodeficiency Virus ...

    • Omics and Male Infertility: Highlighting the Application of Transcriptomic Data 

      Omolaoye, Temidayo S.; Omolaoye, Victor A.; Kandasamy, Richard Kumaran; Hachim, Mahmood Yaseen; Du Plessis, Stefan S. (Peer reviewed; Journal article, 2022)
      Male infertility is a multifaceted disorder affecting approximately 50% of male partners in infertile couples. Over the years, male infertility has been diagnosed mainly through semen analysis, hormone evaluations, medical ...

    • Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines 

      Lee, Seung-Eun; Song, JongKeon; Bösl, Korbinian; Müller, André C.; Vitko, Dijana; Bennett, Keiryn L.; Superti-Furga, Giulio; Pandey, Akhilesh; Kandasamy, Richard Kumaran; Kim, Min-Sik (Journal article, 2018)
      Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19,837 protein-coding genes have been annotated in the neXtProt ...

    • The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function 

      Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2020)
      CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate ...

    • Revisiting Regulated Cell Death Responses in Viral Infections 

      Rex, Devasahayam Arokia Balaya; Keshava Prasad, Thottethodi Subrahmanya; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      The fate of a viral infection in the host begins with various types of cellular responses, such as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and pyroptosis are the three major types ...

    • SLAMF1 is required for TLR4-mediated TRAM-TRIF dependent signaling in human macrophages 

      Yurchenko, Mariya; Skjesol, Astrid; Ryan, Liv; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Wang, Ninghai; Terhorst, Cox; Husebye, Harald; Espevik, Terje (Journal article; Peer reviewed, 2018)
      Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells. In this study, we report that SLAMF1 ...